Constituents of picralima nitida display pronounced inhibitory activities against asexual erythrocytic forms of plasmodium falciparum in vitro. Picralima nitida is a west african plant with varied applications in african folk medicine. This work was aimed to determine the toxicological parameters of the aqueous. It is a native to western africa particularly ghana, ivory coast and nigeria. Research article antidiabetic property of picralima nitida. Medicinal uses, phytochemistry and pharmacology of picralima nitida. Its fruits are ovoid and yellowish at maturity adjanohoun et al.
Pseudoakuammigine, an alkaloid from picralima nitida seeds, has antiinflammatory and analgesic actions in rats chemosystematic value of cyclopeptide alkaloids from heisteria nitida olacaceae original mechanisms of antipsychotic action by the indole alkaloid alstonine picralima nitida. Evaluation of picralima nitida acute toxicity in the mouse koffi ng, emma aa, stephane dk abstract picralima nitida is a small tree used in a wide range by traditional medicine to cure various pathologies. Toxicopathological evaluation of picralima nitida seed. This plant is widely distributed throughout africa forest regions. Firstly, picralima nitida plant is a tree that can reach a height of 35 meters, but is usually less. Picralima nitida seeds can be dried and stored for 0. However, in some areas with a high human population pressure, the species has become scarce because of its use as. It is an opiate, but its action is principally on the kappa opioid receptor, as such it is not a plant that gives you direct spiritual experience in the way that opium or morphine does. All reports are erowid and you agree not to download or analyze the report data without contacting erowid center and receiving permission first.
Phytochemical screening and toxicological profile of. International journal of pharmacy publishes effects of. The antiplasmodial activities of organic and aqueous extracts from the west african plant picralima nitida. Constituents of picralima nitida display pronounced inhibitory. Chronic oral consumption of ethanolic extract of picralima nitida. Optimization of polycondensation process of alkyd resin.
Toxicopathological evaluation of picralima nitida seed aqueous. Plant extract as biodegradable inhibitor for zinc in. Picralima nitida is a medicinal plant with diverse end uses. Usda, ars, germplasm resources information network. General 1, first times 2, preparation recipes 30, alone 16 copyrights. Access is allocated within two business days of purchase and lasts one year. Pdf medicinal uses, phytochemistry and pharmacology of. The basic fraction bf of the methanol extract of the stem bark of picralima nitida family apocynaceae exhibited significant antimicrobial activity against a wide range of gram. The plant has wide varied applications in nigeria herbal medicine.
Pdf evaluation of antiplasmodial activity of ethanolic seed extract. In traditional african medicine, picralima nitida seeds are used for the treatment of malaria and diarrhoea. Picralima nitida seed extract pne has aphrodisiac and contraceptive effect. The fruit pulp, possesses hypoglycaemic properties. Apocynaceae and order gentianales is a widely distributed medicinal plant that grows in the tropical rainforests of africa, as homesteads or bushes 4, 5. Insecticides resistance and the corresponding health and environmental challenges that arises as a result of the use of synthetic chemical based insecticides prompts the search for better alternative control measures which are more effective. Akuamma seed powder report picralima nitida ive been off kratom for about 44 days. Picralima nitida, biochemical parameter, sickle cell blood, methanol extract and fraction, abstract the study determined the effects of methanol extract and fractions of p. Evaluation of the antimicrobial property of the stem bark. Durand family apocynaceae isolectotype of picralima klaineana pierre family apocynaceae previous.
The methanol m extract of the fruitrinds of picralima nitida pn was analyzed phytochemically and evaluated for its toxicity effect in wistar rats. Picralima nitida is a widely used medicinal plant in west africa for treating malaria, diarrhea and inflammation. Ive been in limbo on whether or not to order more kratom, or say goodbye forever if the worst case scenario happens. Emergence of insecticide resistant strains of the mosquitoes poses a serious threat and hence calls for alternative control measures. Fruits of picralima nitida were cut into small pieces and dried under sunlight and subsequently pulverized with manual grinder into coarse powder. Picralima nitida akuamma commonly called asewa in ibibio dialect is a rainforest tree rich in alkaloids occurring in african forest region. The size and length of the combs of white leghorn dayold chicks treated with testosterone 0. Antioxidant and antidiabetic profiles of two african medicinal plants. Pdf constituents of picralima nitida display pronounced. Picralima nitida is a member of the family apocynaceae. Picralima nitida is a medicinal plant with diverse end uses keay, 1989 extracts from its seeds, fruit rind and stem bark demonstrated antimalarial activity iwu. It is known as limeme congo, eban, obero gabon, erin yoruba, osuigwe igbo, bamborutuk, eban cameroon. Picralima nitida seeds contain a mixture of alkaloids producing antipyretic and antiinflammatory. The results of this study showed that the essential oils of picralima nitida seeds were predominated by monoterpenes and sesquiterpenes and with high possibility of finding applications in therapy as an anticancer agent and antifungal.
Acute and subacute effects of aqueous extract of picralima. However, the oil should be scientifically evaluated so as to. All structured data from the file and property namespaces is available under the creative commons cc0 license. Media in category picralima nitida the following 12 files are in this category, out of 12 total. It is a commonly used herbal remedy in west africa. Apocynaceae is a west african plant with varied applications in african folk medicine. Fifteen successfully mated female rats were divided into three groups of five animals each. Collected mass spectrometry data on monoterpene indole. Picralima nitida is an entirely glabrous shrub of 310 m high. Medicinal uses, phytochemistry and pharmacology of picralima. The extract cleared the parasite completely from the t.
This study reports the in vitro and in vivo antishigellosis activity of the methanol extract of this plant on rats. But it heals and is useful as a means of healing as such it is worthwhile including it. In vitro uterotonic effects of ethanolic fruit extract of. Evaluation of antiplasmodial activity of ethanolic seed extract of picralima nitida author links open overlay panel jude e. These seeds are known to contain kratomlike alkaloids, so i obtained 100 grams of ground akuamma seed powder from an online vendor and started a new study.
Toxicopathological evaluation of picralima nitida seed aqueous extract in wistar rats. The objective of this study is to evaluate the toxicological. In vitro uterotonic effects of ethanolic fruit extract of picralima nitida. Picralima nitida apocynaceae family is one of such medicinal plants. Their structures were elucidated by analysis of their hrms and nmr spectroscopic data, and their absolute configurations were deduced from the comparison of experimental and simulated ecd spectra. Picralima nitida apocynaceae and sonchus oleraceus asteraceae. From the foregoing, it is obvious that several works have diversely investigated the effects of. It is used as a painkiller and for its antipyretic, antidiabetic and antiinflammatory effects. The board of trustees of the royal botanic gardens, kew. This page was last edited on 16 october 2018, at 10. Groups 1 and 2 received intraperitoneal injection of 50 and 500 mgkg body weight of the extract dissolved in distilled water, respectively, on.
Pdf the seed extract of picralima nitida was screened for hypoglycaemic activity. Various parts of the plant have been employed ethnomedicinally as remedy for fever, hypertension, jaundice, dysmenorrheal, gastrointestinal disorders and malaria. Research article open access the antishigellosis activity. Picralima nitida commonly known as akuamma is a tree which has been used primarily for its high potential effect in herbal medicines. Picralima nitida stapf apocynaceae is a medicinal plant used traditionally in cameroon to cure various ailments such as gastrointestinal disorders and dysentery. Larvicidal activity of picralima nitida, an approach in. The seeds are crushed or powdered and taken orally, and are traditionally mainly used for the treatment of malaria, diarrhoea, and as a painkiller. Akuamma seed powder are often related to kratom because of its alkaloid shares similarities with kratom active alkaloids mitragynine. Picralima nitida akuamma seeds akuammine seeds from. Pdf screening of the seed of picralima nitida for hypoglycaemic. The dried akuamma seeds from this plant are used in traditional remedies throughout west africa, particularly in ghana.
Akuammine is the most abundant active alkaloid found in the seeds from the tree picralima nitida, commonly known as akuamma. Male rats were divided into five groups for acute and subacute study. Evaluation of picralima nitida acute toxicity in the mouse. Aqueous extract of seeds of picralima nitida was used to evaluate its protective effect on dexamethasoneinduced insulinresistance in rats. Picralima is a plant genus in the family apocynaceae, first described as a genus in 1896. This data descriptor announces the submission to public repositories of the monoterpene indole alkaloid database miadb, a cumulative collection of. Manual of the materia medica, gave 61 possible remedies for cough eccles. Files are available under licenses specified on their description page. In vitro and in vivo antitrypanosomal effects of methanol. Journal of ethnopharmacology 111 2007 464467 evaluation of antiplasmodial activity of ethanolic seed extract of picralima nitida jude e. International research journal of pharmaceutical and. Picralima nitida seeds contain a mixture of alkaloids producing antipyretic and antiinflammatory effects along with analgesia in animal studies.
Medicinal uses, phytochemistry and pharmacology of. Picralima nitida is a common species of the african forest zone, and is not threatened by genetic erosion. To investigate the effect of pne on reproductive hormones. When fully grown, it is about 20 m high with white flowers and large paired fruits. Pdf an investigation of the lethality of picralima. The available evidences in this study suggest that aqueous extract of p. After having lost access to kratom leaf for research in my local area, i searched for a natural product similar to kratom and found picralima nitida seeds, better known as akuamma.
Assessment of an ethanolic seed extract of picralima. It is a wildly grown tree and widely distributed in the tropical rain forests of africa. Picralima nitida stapf is a bonafide member of the family apocynaceae and restricted in distribution to african rain forest regions. The ethanolic fruit extract of picralima nitida stapf which proved to be a potent spasmogen in vitro was tested in pregnant female sprague dawley rats. Ethanol, benzene, chloroform and aqueous cold and hot extracts of picralima nitida seed, stembark and root were tested against five bacterial strians using.
It contains only one known species, picralima nitida, native to tropical africa. Optimization of corrosion inhibition of picralima nitida. Effects of ethanolic fruit extract of picralima nitida. Evaluation of antiplasmodial activity of ethanolic seed. Five new monoterpene indole alkaloids 15, including four serpentininerelated bisindoles and one alstonine derivative monomer, have been isolated from the aerial parts of picralima nitida. Picralima in world checklist of selected plant families.
The methanol extract of the root of picralima nitida showed the highest in vivo antitrypanosomal activity at 100 mgkg body weight. The study aims to evaluate the blood sugar reduction activity of seed oil extracted from the seed of picralima nitida and to compare its intraperitonial and oral administration with that of seed. Scholars research library chemical compositions of. Picralima nitida in the germplasm resources information network grin, u. All parts of the plant are bitter throughout its distribution area. International research journal of pharmaceutical and applied sciences irjpas available online at.
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